January 20: Welcome

9:30 Leave Durban
12:30 Arrival at St. Lucia
13:30 Lunch
16:00 Workshop opening at the Ecolodge conference room
16:30 Welcome from the community. Robert Ndlazi, Deputy Secretary of the Community Advisory Board, Somkhele.
16:35 Welcome to the Workshop. Alex Sigal, Max Planck Society Research Group Leader, AHRI.
16:50 Opening talk: Basic science for the good of humankind – The Max Planck Society. Bill Hansson, Vice-President, Max Planck Society.
17:20 Wellcome funding in LMICs. Mike Turner, Director of Science, Wellcome Trust.
17:40 HIV and TB Research at AHRI. Thumbi Ndung’u, Max Planck Society Research Group Leader and Deputy Director, AHRI.
18:00 Keynote: Achieving an HIV Remission: Viable Pathways and Recent Advances. Steve Deeks, UCSF.
19:00 Dinner

January 21: Evolution

07:30-09:00 Breakfast
Session 1: Evolution and the HIV Reservoir. Chair: Alex Sigal.
09:00 Establishment and maintenance of the latent HIV-1 DNA reservoir. Richard Neher, University of Basel.
09:20 Stochastic drift, novel interactions, extinctions: Evolutionary dynamics beyond recurrent selection events.
Arne Traulsen, Max Planck Institute for Evolutionary Biology.
09:40 The CNS is a site of HIV persistence which can lead to virologic failure. Gil Lustig, AHRI.
10:00 Is there HIV diversification and immune selection in lymph nodes in antiretroviral treated patients? Jaclyn Mann, Human Pathogenesis Program, UKZN.
10:15 Complementation of HIV leads to quasispecies formation. Laurelle Jackson, AHRI.
10:30-11:00  Coffee Break
Session 2: Evolutionary dynamics and establishment of infection. Chair: Mike Turner.
11:00 Vukuzazi: next-generation population science in rural KwaZulu-Natal. Emily Wong, AHRI.
11:20 Vectored ImmunoTherapy and Escape from bNAbs. Alex Balazs, Ragon Institute.
11:40 ADCC drives escape in early HIV-1 infection.  Carolyn Williamson, UCT.
12:00 Can HIV-1(M) Gag facilitate pandemic transmission levels through adaptation to evade innate immune sensing? Greg Towers, UCL.
12:20 Complete mapping of the functional and antigenic effects of mutations to HIV Env. Adam Dingens, Fred Hutchinson Cancer Research Center.
12:40 Transmitted/founder viruses and selective pressures following establishment of infection.  Kamini Gounder, Human Pathogenesis Program, UKZN.
13:00 Lunch
15:00 Hippo and Croc Cruise onto the St. Lucia Estuary.
18:00 Braai

January 22: Reservoirs

07:30-09:00 Breakfast
Session 3: Mechanisms of control in early ART initiation. Chair: Mike McCune.
09:00 Mechanisms of durable virological remission in post treatment controllers. Asier Sáez-Cirión, Institut Pasteur.
09:20 HIV cure in paediatric infection. Philip Goulder, Oxford.
09:40 Post-treatment control of HIV: Clues from “The South African child”. Caroline Tiemessen, Wits and NICD.
10:00 Early ART initiation during hyperacute HIV-1 infection preserves T follicular helper cell function. Omolara Baiyegunhi, AHRI.
10:15 Characterization of the HIV reservoir in women treated with antiretroviral therapy during acute HIV infection. Kavidha Reddy, AHRI.
10:30-11:00 Coffee break
Session 4: Establishment and maintenance of the HIV reservoir. Chair: Steve Deeks.
11:00 Use of SeqWell single cell RNA-Seq for detection of HIV reservoir cells. Carly Ziegler, MIT.
11:20 Immunotherapeutic ImmTAV molecules for targeting HIV infection. Jacqui Brener, Immunocore.
11:40 HIV antibodies and viral reservoirs. Laura McCoy, UCL.
12:00 Evidence of persistent HIV-1 infection in lymph node tissues following extremely early initiation of antiretroviral therapy. Zaza Ndhlovu, AHRI.
12:20 Timing of the establishment of the HIV-1 latent reservoir. Melissa-Rose Abrahams, UCT.
12:40 Epigenetic Regulation of HIV Latency. Melanie Ott, UCSF/Gladstone.
13:00-14:30 Lunch
Session 5: Genetic, anatomical, and population landscape of the reservoir. Chair: Thumbi Ndung’u.
14:30 Mapping the HIV latency circuit. Leor Weinberger, UCSF/Gladstone.
14:50 Distinct chromosomal positions of intact HIV-1 proviruses. Mathias Lichterfeld, Harvard.
15:10 Perturbing cellular gene expression reveals a functional link between HIV-1 integration site selection, viral gene expression and T-cell activation. Ari Fassati, UCL.
15:30 Compartment specific CD4 T-cell depletion in the HIV infected gut is associated with differential integrin expression.  Henrik Kloverpris, AHRI.
15:50 What we can learn about viral reservoirs from kids. Nigel Klein, UCL.
16:10-16:40 Coffee break
Session 6: Cellular reservoirs and co-infection. Chairs: Desh Archary and Nigel Garrett.
16:40 Cell-cell spread of HIV. Clare Jolly, UCL.
17:00 The impact of HIV infection on lung immunity in the era of antiretroviral therapy. Henry Mwandumba, Malawi-Liverpool-Wellcome Trust.
17:20 TB and HIV, and the myeloid cells of the lung. David Russell, Cornell.
17:40 Macrophage Reservoirs for HIV-1. Ravi Gupta, UCL.
18:00 Defining the immune landscape of HIV infected human lungs using single cell RNA sequencing. Al Leslie, AHRI.
18:20 Using the tools of Systems Biology to identify molecular signatures that enable the stratification of TB and SIV infection. Alan Aderem, Center for Infectious Disease Research.
19:00 Dinner

January 23: Close and trip to Demographic Surveillance Area

07:30-09:00 Breakfast
08:00 Leave for Somkhele AHRI Demographic Surveillance Area for those who registered for the visit.
10:00 Check out from St. Lucia Eco Lodge.